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. 2019 Jun 13;216(8):1904–1924. doi: 10.1084/jem.20181657

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© 2019 Bersellini Farinotti et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 6. — CII-IC stimulation of DRG cell cultures leads to increased neuronal excitability. (A) FcγRI and FcγRIIb are expressed in BALB/c mouse DRG neurons in culture as shown by colocalization with βIII-tubulin. Scale bars represent 10 µm. (B and C) CII-IC stimulation of BALB/c mouse DRG cell cultures resulted in increased intracellular [Ca²⁺] signal (B) and also evoked positive inward currents (C). (D and E) CII-IC stimulation evoked CGRP release in DRG cell cultures from WT BALB/c mice (D) but not from FcRγ-chain^−/− mice (E). Capsaicin (CAP) was used as positive control. Data are presented as mean ± SEM. ***, P < 0.001.