Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 17;216(8):1891–1903. doi: 10.1084/jem.20182238

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Fan et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 3. — Overexpression of CX3CL1-ct in 5xFAD transgenic mice reduces amyloid deposition. (A) Two different pairs of Tg-5xFAD and Tg-CX3CL1-ct/tTA/5xFAD mice were used for comparing the density of amyloid plaques by confocal or DAB staining. Antibody 6E10 recognizes human Aβ peptides and amyloid plaques, while HA-tagged CX3CL1-ct transgene was detected with HA antibody. Cell nucleus was marked by Topro. Scale bars, 200 µm. (B) Densities of amyloid plaques from subiculum or cortex were quantified from six mice in each pair. Both male and female mice were used for comparisons. Error bars are ± SEM. (C) APP and its cleavage product C99 and C83 were examined by antibody 8717 (n = 3 experiments). **, P < 0.01; ***, P < 0.001.