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. 2019 Jun 17;216(8):1891–1903. doi: 10.1084/jem.20182238

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© 2019 Fan et al.

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Figure 6. — CX3CL1-ct enhances neurogenesis in adult transgenic mice. (A) Tg-CX3CL1-ct/tTA mice that were treated with Dox for 2 mo (2M) and left untreated for another 4 mo (4M) were pulse labeled for examination of adult neurogenesis. Fixed brain sections were reacted with antibody for BrdU and Topro for the nucleus. (B) Semiquantification was conducted using one in every six sections to compare BrdU-positive cells in the Tg-CX3CL1-ct/tTA SGZ with that in WT (n = 4; ***, P < 0.001, Student’s t test). Each animal is shown in one dot. Error bars are ± SEM. (C) BrdU⁺ cells in Tg-CX3CL1-ct/tTA SVZ were significantly increased compared with WT SVZ. Scale bars, 60 µm.