Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 17;216(8):1891–1903. doi: 10.1084/jem.20182238

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Fan et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 8. — Increased TGFβ signaling and neurogenesis by expressing CX3CL1-ct in adult mice. (A) Protein levels were compared between transgenic mice (Tg-CX3cl1-ct/tTA) and their control littermates (WT, Tg-Cx3CL1-ct and Tg-CamKIIa-tTA) using the indicated antibodies. Expression of transgene CX3CL1-ct was validated by HA and CX3CL1 antibody in compound mice. BACE1-cleaved C-terminal fragment was marked by β, and ADAM-cleaved fragment, by α. (B) Bar graphs confirm that neuronal expression of CX3CL1-ct significantly increases levels of TGFβ2, TGFβ3, p-Smad2, and p-Smad3 compared with controls (n = 3 experiments; **, P < 0.01; ***, P < 0.001, Student’s t test; error bars are ± SEM).