TABLE 2.
Suggested functions of identified SNVs and their respective genes
| Suggested mechanism of action | Gene | SNV (amino acid change at codon) |
Study suggesting mechanism of action |
|---|---|---|---|
| Potential new drug resistance markers | ettA (Rv2477c) | W135G | Faksri et al. (52) |
| katG (Rv1908c) | L101R | Datta et al. (53) | |
| katG (Rv1908c) | A290P | Manson et al. (46) | |
| katG (Rv1908c) | L427P | Manson et al. (46) | |
| fadE24 (Rv3139) | R454S | Manson et al. (46) | |
| fabD (Rv2243) | A159T | Manson et al. (46) | |
| Associated with relapse and survival | eccB3 (Rv0283) | Witney et al. (44) | |
| mce1B (Rv0170) | Witney et al. (44) | ||
| bacA (Rv1819c) | Frame shift (insG) | Stinear et al. (38) | |
| Rv2326c | Frame shift (insC) | Stinear et al. (38) | |
| Potentially involved in compensatory mechanisms | rpoC (Rv0668) | Several | Comas et al. (47), Wollenberg et al. (92) |
| rpoA (Rv3457c) | Several | Comas et al. (47), Wollenberg et al. (92) | |
| Rv0888 | 360delG | Leung et al. (48) | |
| cobM (Rv2071) | 199_204del | Leung et al. (48) | |
| lpdA (Rv3303c) | V44I | Leung et al. (48) | |
| fadD32 (Rv3801c) | E444G | Sun et al. (29) | |
| fadE33 (Rv3564) | O'Neill et al. (39) | ||
| lprO (Rv0179c) | O'Neill et al. (39) | ||
| Associated with virulence | mce3R (Rv1963c) | Navarro et al. (19) | |