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. 2019 Aug 6;15(8):e1007090. doi: 10.1371/journal.pcbi.1007090

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© 2019 Bag et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — (A) The SM pairs and interconnecting paths between them that have a significant impact on EGFR-mediated GBM were filtered from the GBM-specific network using the mathematical model of Fig 5 and combined to generate the final signaling-metabolic interconnected network. The network parameters (color code of node and edge, node size, edge width mentioned in the figure) signified the cell-biological consequences of GBM driven by constitutive EGFR signaling. One representative signaling–metabolic connecting path for each of the fourteen signaling pathways is indicated at the side of the network.(B) Sub-network based on the 15 top-ranked signaling cross-talk proteins and their interconnection with all metabolic pathways.