Table 2. Oncogenic driver mutations in never smokers.
| EGFR mutation (n = 81) | ||||
| cDNA change | Amino acid change | Frequency | Percentage | |
| Exon 21 | c.2573T>G | p.L858R | 26 | 32.1 |
| Exon 21 | c.2497T>G | p.L833V | 1 | 1.2 |
| Exon 21 | c.2560A>G | p.T854A | 1 | 1.2 |
| Exon 21 | c.2579A>T | p.K860I | 1 | 1.2 |
| Exon 20 | c.2303_2311dup | p.S768_D770dup | 2 | 2.5 |
| Exon 20 | c.2303G>T | p.S768I | 2 | 2.5 |
| Exon 20 | c.2320G>A | p.V774M | 1 | 1.2 |
| Exon 20 | c.2389T>A | p.C797S | 1 | 1.2 |
| Exon 20 | c.2320_2321insCACATG | p.H773_V774insAH | 1 | 1.2 |
| Exon 20 | c.2310_2311insGGGC | p.D770_N771insG | 1 | 1.2 |
| Exon 20 | c.2317_2322 | p.H773_V774dup | 1 | 1.2 |
| Exon 19 | c.2235_2249del/c.2236_2250del† | p.E746_A750del | 26 | 32.1 |
| Exon 19 | c.2240_2257del | p.L747_P753delinsS | 5 | 6.2 |
| Exon 19 | c.2237_2255delinsT | p.E746_S752delinsV | 3 | 3.7 |
| Exon 19 | c.2254_2277del | p.S752_I759del | 2 | 2.5 |
| Exon 19 | c.2240_2254del | p.L747_T751del | 2 | 2.5 |
| Exon 19 | c.2239_2256del | p.L747_S752del | 2 | 2.5 |
| Exon 19 | c.2239_2252delinsCA | p.L747_T751delinsQ | 1 | 1.2 |
| Exon 19 | c.2239_2248delinsC | p.L747_A750delinsP | 1 | 1.2 |
| Exon 19 | c.2239_2258delinsCA | p.L747_P753delinsQ | 1 | 1.2 |
| Exon 19 | c.2239_2251delinsC | p.L747_T751delinsP | 1 | 1.2 |
| Exon 19 | c.2251_2277del | p.T751_I759delinsS | 1 | 1.2 |
| Exon 19 | c.2281G>T | p.D761Y | 1 | 1.2 |
| Exon 18 | c.2156G>C | p.G719A | 2 | 2.5 |
| Exon 18 | c.2126A>C | p.E709A | 1 | 1.2 |
| Exon 18 | c.2126A>G | p.E709G | 1 | 1.2 |
| Exon 18 | c.2155G>T | p.G719C | 1 | 1.2 |
| Exon 18 | c.2142G>C | p.K714N | 1 | 1.2 |
| KRAS mutations (n = 6) | ||||
| cDNA change | Amino acid change | Frequency | Percentage | |
| Codon 12/Exon 2 | c.35G>T | p.G12V | 3 | 50.0 |
| Codon 12/Exon 2 | c.34G>T | p.G12C | 1 | 16.7 |
| Codon 12/Exon 2 | c.35G>A | p.G12D | 1 | 16.7 |
| Codon 61/Exon 3 | c.182A>T | p.Q61L | 1 | 16.7 |
| BRAF mutations (n = 3) | ||||
| cDNA change | Amino acid change | Frequency | Percentage | |
| Exon 15 | c.1799T>A | p.V600E | 2 | 66.7 |
| Exon 15 | c.1799T>A | p.V600G | 1 | 33.3 |
| ERBB2 mutations (n = 6) | ||||
| cDNA change | Amino acid change | Frequency | Percentage | |
| Exon 20 | c.2324_2325ins | p.E770_A771ins | 1 | 16.7 |
| Exon 20 | c.2313_2324dup | p.A771_M774dup | 2 | 33.3 |
| Exon 20 | c.2326_2327insTGT | p.G776delinsVC | 1 | 16.7 |
| Exon 20 | c.2310_2311ins12 | p.E770_A771insAYVM | 1 | 16.7 |
| Exon 20 | c.2331_2339dup | p.G778_P780dup | 1 | 16.7 |
| PIK3CA (n = 4) | ||||
| cDNA change | Amino acid change | Frequency | Percentage | |
| Exon 10 | c.1633G>A | p.E545K | 2 | 50.0 |
| Exon 10 | c.1624G>A | p.E542K | 1 | 25.0 |
| Exon 21 | c.3140A>G | p.H1047R | 1 | 25.0 |
†c.2235_2249del: n = 18; c.2236_2250del: n = 8.