Fig 8. Schema depicting the overall difference in water regulation in the Atp6v1b1^-/- mice compared to WT.

Ablation of the V-ATPase B1 subunit decreases the urine concentrating ability of mice both under baseline conditions and after dehydration. Loss of the B1 subunit eliminates the apparent advantage in water concentrating ability of female animals over the male animals that was found in WT mice.