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. 2019 Aug 6;14(8):e0220382. doi: 10.1371/journal.pone.0220382

Fig 4. Effect of dissolving-microneedle-patch loaded OVA on splenocytes and lymphocytes proliferation in mice.

Fig 4

The mice (n = 4/group) were immunized either using the dissolving-microneedle-patch or dissolving-microneedle-patch loaded OVA. The splenocytes and lymphocytes of each group were re-stimulated with OVA 7 days after the last immunization. The proliferation was assessed using a Bromo-kit. The culture supernatants were harvested after 24 h, and the cytokine levels were measured by ELISA. Data are represented as mean ± SD of four mice per group. *p<0.05, **p<0.01 or **p<0.001 (-) vs. re-stimulation OVA. Per group. #p<0.05, ## p<0.01 or ### p<0.001 control-patch group vs. OVA-patch group. Digital Object Identifier: 10.6084/m9.figshare.7679675.