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. 2019 Aug 6;14(8):e0220382. doi: 10.1371/journal.pone.0220382

Fig 5. Effect of dissolving-microneedle-patch loaded OVA on OVA-specific T cell response in mice.

Fig 5

The mice (n = 4/group) were immunized either using the dissolving-microneedle-patch or dissolving-microneedle-patch loaded OVA. The splenocytes of each group were re-stimulated with OVA 7 days after the last immunization and CD4+, and CD8+ T cells were then gated and analyzed using a FACScanto II (BD Biosciences) by staining with FITC-anti-IFN-γ and PE-anti-CD4/CD8. Data are represented as mean ± SD of four mice per group. *p<0.05, **p<0.01 or **p<0.001 (-) vs. re-stimulation OVA. per group. #p<0.05, ## p<0.01 or ### p<0.001 control-patch group vs. OVA-patch group. Digital Object Identifier: 10.6084/m9.figshare.7726043.