Fig 6.

(A) Immunization by dissolving-microneedle-patch loaded OVA induces OVA-specific CTL activity and (B) cytokine levels (IFN-ɣ). The mice (n = 4/group) were immunized either using the dissolving-microneedle-patch or dissolving-microneedle-patch loaded OVA. 7 days after the last immunization, the mice were sacrificed and the splenocytes of each group were harvested for the in vitro killing assay (E/T = 50, and 100). Data are represented as mean ± SD of four mice per group. ^#p<0.05, ^## p<0.01 or ^### p<0.001 control-patch group vs. OVA-patch group. Digital Object Identifier: 10.6084/m9.figshare.7679693.