Table 4. Immunization by dissolving-microneedle-patch loaded OVA induces OVA-specific CTL activity and cytokine levels (IFN-ɣ).
| CD8+ T cell Cytotoxicity | |||||||||
| mice | 1 | 2 | 3 | 4 | mean | s.d | |||
| Cytotoxicity, % |
Cont-Patch | E:T | 50:1 | 8.59 | 3.58 | 5.26 | 7.87 | 6.33 | 2.3 |
| 100:1 | 8.78 | -10.8 | 16.45 | 13.48 | 6.98 | 12.3 | |||
| OVA-Patch | E:T | 50:1 | 14.6 | 14.63 | 24.25 | 16.76 | 17.56 | 4.6 | |
| 100:1 | 23.69 | 25.41 | 19.76 | 16.95 | 21.45 | 3.8 | |||
| CD8+/IFN-Ɣ+ | |||||||||
| mice | 1 | 2 | 3 | 4 | mean | s.d | |||
| Cytokine (pg/ml) |
Cont-Patch | E:T | 50:1 | 26.50 | 379.00 | 416.50 | 500.25 | 330.56 | 208.9 |
| 100:1 | -198.50 | 247.75 | 349.00 | 645.25 | 260.88 | 349.6 | |||
| OVA-Patch | E:T | 50:1 | 862.75 | 970.25 | 1145.25 | 1290.25 | 1067.13 | 188.9 | |
| 100:1 | 854.00 | 981.50 | 1260.25 | 1579.00 | 1168.69 | 321.9 | |||