Table III.
Inflammatory and neurotrophic proteins through LCA*
| IRG 1 Low elevation (n = 634) | IRG 2† ≥3 Elevated proteins including CRP or SAA (n = 130) | IRG 3‡ ≥3 Elevated proteins Not CRP or SAA (n = 48) | |
|---|---|---|---|
| IRG | |||
| CRP | 6.8 | 86.9 | .0 |
| SAA | 6.9 | 68.5 | .0 |
| IL-1β | 7.1 | 43.8 | 62.5 |
| IL-6 | 6.1 | 51.5 | 52.1 |
| TNF-alpha | 7.4 | 54.6 | 75.0 |
| IL-8 | 4.3 | 58.5 | 68.7 |
| ICAM-1 | 8.4 | 62.3 | 39.6 |
| MMP-9 | 8.5 | 33.1 | 56.2 |
| NRG 1 Low Elevation (n = 552) | NRG 2§ 2 of RANTES, BDNF, Ang-1 Elevated (n = 133) | NRG 3¶ 3 + Other Proteins Elevated (n = 127) | |
| NRG | |||
| RANTES | 5.8 | 77.4 | 12.6 |
| BDNF | 5.8 | 85.7 | 5.7 |
| Ang-1 | 2.1 | 87.2 | 12.3 |
| IL-6R | 7.2 | 43.6 | 51.2 |
| BFGF | 6.2 | 28.6 | 48.4 |
| IGF-1 | 13.6 | 17.3 | 41.0 |
| VEGF | 10.1 | 42.9 | 40.9 |
| VEGF-R1 | 10.2 | 30.1 | 40.9 |
| VEGF-R2 | 7.4 | 51.1 | 40.9 |
| PIGF | 8.2 | 19.5 | 41.0 |
| Ang-2 | 5.6 | 42.9 | 36.9 |
| TSH | 14.1 | 26.3 | 40.9 |
BFGF, Basic fibroblast growth factor; ICAM-1, intercellular adhesion molecule-1; IGF, insulin-like growth factor; IL, interleukin; MMP, matrix metallopeptidase; PIGF, placental growth factor; TNF, tumor necrosis factor; TSH, thyroid-stimulating hormone; VEGF, vascular endothelial growth factor.
The columns represent the percentage for each protein listed on the left that have sustained highest quartile value in each of the 3 inflammatory or neurotrophic risk groups of children.
IRG2 has a preponderance of high values for CRP and SAA and lesser elevations of the other proteins.
IRG3 has a reduced likelihood of having high values for CRP or SAA while having elevated values of the other inflammatory proteins.
NRG2 has a preponderance of high values for RANTES, BDNF, and Ang-1 and lesser elevations of the other proteins.
NRG3 has reduced likelihood of having high values for RANTES, BDNF, and Ang-1, while having elevated values of the other neurotrophic proteins.