Table V.

Impairment on LCA measure^*

	LCA-based cognitive impairment level (n = 812)
	Severe n = 64	Moderate n = 135	Low Normal n = 333	Normal n = 280
Elevated inflammatory proteins
0–1	Ref	Ref	Ref	Ref
2–3	1.67 (0.75–3.73)	3.47 (1.98–6.09)	1.34 (0.84–2.14)	Ref
≥4	5.68 (2.30–14.00)	5.89 (2.83–12.24)	2.72 (1.49–4.99)	Ref
Elevated neurotrophic proteins
0–1	Ref	Ref	Ref	Ref
2–3	0.48 (0.24–0.97)	0.70 (0.41–1.19)	0.66 (0.44–0.99)	Ref
≥4	0.22 (0.09–0.53)	0.35 (0.18–0.67)	0.63 (0.39–1.00)	Ref

Values are adjusted OR (95% CI).

Bold values represent ORs for which the 95% confidence limits do not include 1; ie, significantly different from 1 at P < .05.

^*At 10 years of age for those with elevated inflammatory and neurotrophic proteins on 2 of the first 3 postnatal measurements (controlling for infant sex, maternal education, and the other set of proteins).