Table VI.

Cognitive impairment^*

	LCA-based cognitive impairment level (n = 812)
	Severe n = 64	Moderate n = 135	Low Normal n = 333	Normal n = 280
Elevated inflammatory proteins
IRG1	Ref	Ref	Ref	Ref
IRG2	3.79 (1.72–8.36)	3.93 (2.08–7.41)	2.54 (1.48–4.34)	Ref
IRG3	2.18 (0.61–7.78)	3.18 (1.29–7.83)	1.53 (0.69–3.38)	Ref
Elevated neurotrophic proteins
NRG1	Ref	Ref	Ref	Ref
NRG2	0.31 (0.12–0.79)	0.46 (0.24–0.88)	0.62 (0.39–0.98)	Ref
NRG3	0.85 (0.37–1.95)	1.03 (0.55–1.95)	1.00 (0.60–1.67)	Ref

IRG2 defined by elevation of CRP or SAA with other proteins having little or modest elevations.

IRG3 defined by ≥3 other protein elevations without CRP and SAA elevations.

NRG2 defined by elevation of 2 of RANTES, BDNF, or ANG-1 with other proteins having little or modest elevations.

NRG3 defined by ≥3 other proteins elevated protein elevations without CRP and SAA elevations.

Values are adjusted OR (95% CI).

Bold values represent ORs for which the 95% confidence limits do not include 1; ie, significantly different from 1 at P < .05.

^*At 10 years of age for those with sustained elevated inflammatory and neurotrophic proteins (controlling for infant sex and maternal education).