Table 1.

Dose level allocation by group

Group	Dose allocation
1 (less frail)	$\text{min}\left\{\text{max}\left(d_1^{max},d_2^{max},d_3^{max}\right)+1,K\right\}$
2 (less frail)	$\text{min}\left\{\text{max}\left(d_1^{max},d_2^{max},d_3^{max}\right)+1,K\right\}$
3 (most frail)	$\text{min}\left\{d_3^{max}+1,K\right\}$