Table 1.
Potential Effects of PPN DBS in Various Disorders
| Disorder | Symptom | Effect of PPN DBS |
|---|---|---|
| Neurological | ||
| Parkinson’s Disease | Increased REM sleep | Decrease REM sleep |
| Fragmented sleep | Normalize sleep | |
| Insomnia | Normalize sleep | |
| Cognition | Improve attention | |
| Gait and posture | Improve | |
| Alzheimer’s Disease | Increased gamma | 40–60 Hz negative effect >100 Hz positive effect? |
| Epilepsy | Low frequency EEG | Increase EEG frequency |
| Psychiatric | ||
| Schizophrenia | Fragmented sleep | Normalize sleep |
| Interrupted gamma | Increase gamma | |
| Increased REM sleep | Decrease REM sleep | |
| Bipolar Disorder | Fragmented sleep | Normalize sleep |
| Interrupted gamma | Increase gamma | |
| Increased REM sleep | Decrease REM sleep | |
| Trauma/Other | ||
| Neglect | Contralateral neglect | Increase gamma |
| Decreased arousal | Increase arousal | |
| Coma | Vegetative | Increase gamma |
| Minimally conscious | Increase gamma | |
| Locked-in | Increase gamma | |