Table 1.
Demographics and clinical characteristics of MSA patients
| All MSA Patients 685 (100) |
Male MSA Patients 356 (52) |
Female MSA Patients 329 (48) |
p-valuea | False Discovery Rate adjusted p-values | |
|---|---|---|---|---|---|
| Demographics | |||||
| Age at Onset | 60.9 (9.6) | 60.6 (9.8) | 61.3 (9.3) | 0.8323 | 0.9047 |
| Probable MSA | 594 (87) | 300 (84) | 294 (89) | 0.0498 | 0.0845 |
| Subtype | 0.3019 | 0.4193 | |||
| MSA-P | 430 (63) | 230 (65) | 200 (61) | ||
| MSA-C | 255 (37) | 126 (35) | 129 (39) | ||
| Clinical Features | |||||
| Parkinsonism | 526 (77) | 280 (79) | 246 (70) | 0.2295 | 0.3404 |
| Ataxia | 338 (50) | 176 (50) | 162 (49) | 0.8737 | 0.9101 |
| Falls at any time | 458 (67) | 226 (63) | 232 (71) | 0.0507 | 0.0845 |
| Falls within 3 years | 358 (52) | 170 (48) | 188 (57) | 0.0140 | 0.0318 |
| Bladder Symptoms | 572 (84) | 297 (83) | 275 (84) | 0.9551 | 0.9551 |
| Urinary Catheterization | 111 (16) | 79 (22) | 32 (10) | <0.0001 | 0.0004 |
| Urinary Catheterization within 3 years | 58 (8) | 39 (11) | 19 (6) | 0.0190 | 0.0396 |
| Early Orthostatic Intoleranceb | 240 (35) | 142 (40) | 98 (30) | 0.0056 | 0.0156 |
| Stridor | 176 (26) | 93 (26) | 83 (25) | 0.7887 | 0.9047 |
| Dream enactment behavior | 304 (44) | 161 (45) | 143 (43) | 0.6433 | 0.8041 |
| Autonomic Testing | |||||
| Supine systolic blood pressure | 148 (27.2) | 149 (26.3) | 147 (28.3) | 0.2315 | 0.3404 |
| Supine diastolic blood pressure | 83 (14.9) | 84 (13.1) | 81.1 (16.5) | 0.0091 | 0.0228 |
| Systolic blood pressure at 1 minute | 120 (26.5) | 118 (26.3) | 122 (26.6) | 0.0448 | 0.0845 |
| Diastolic blood pressure at 1 minute | 74 (18.9) | 74 (16.5) | 74.4 (21.3) | 0.7993 | 0.9047 |
| Systolic blood pressure at 5 minutes | 112 (26.5) | 109 (26.3) | 116 (26.2) | 0.0001 | 0.0004 |
| Diastolic blood pressure at 5 minutes | 68 (27.1) | 66 (31.5) | 72 (21) | 0.0036 | 0.0113 |
| Systolic blood pressure drop at 1 minute | 28.4 (22.4) | 31.6 (22.0) | 25.0 (22.5) | <0.0001 | 0.0004 |
| Diastolic blood pressure drop at 1 minute | 7.7 (12.4) | 9.4 (11.1) | 5.8 (13.5) | <0.0001 | 0.0004 |
| Systolic blood pressure drop at 5 minute | 36.1 (30.7) | 41.1 (30.4) | 30.7 (30.1) | <0.0001 | 0.0004 |
| Diastolic blood pressure drop at 5 minute | 10.5 (14.5) | 13.2 (14.5) | 7.7 (14.0) | <0.0001 | 0.0004 |
| Systolic blood pressure <90 mmHg at 5 minutes | 171 (25) | 106 (30) | 65 (20) | 0.0027 | 0.0096 |
| CASS Totalc | 5.50 (2.39) | 5.52 (2.16) | 5.47 (2.62) | 0.3979 | 0.5236 |
Values displayed are mean (standard deviation) for continuous variables and frequency (%) for categorical variables.
a
Between male and female
b
Within 1 year of onset
c
Score ranges from 0 (no abnormalities) to 10 (maximal autonomic failure)
Abbreviations: CASS, composite autonomic severity score; MSA, multiple system atrophy; MSA-C, multiple system atrophy-cerebellar; MSA-P, multiple system atrophy parkinsonism