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. Author manuscript; available in PMC: 2019 Aug 6.
Published in final edited form as: Expert Opin Biol Ther. 2015 Mar 26;15(5):735–747. doi: 10.1517/14712598.2015.1026323
Drug name Tramenitib
Phase III
Indication BRAFV600 mutant metastatic melanoma
Pharmacology Inhibitor of MEK 1 and 2, resulting in growth factor-mediated inhibition of cell signalling and proliferation
Route of administration Oral
Chemical structure N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl) acetamide
Pivotal trial(s) Phase I [15, 26, 32], Phase II [15, 47], Phase III [14, 18, 19]