Drug name | Tramenitib |
Phase | III |
Indication | BRAFV600 mutant metastatic melanoma |
Pharmacology | Inhibitor of MEK 1 and 2, resulting in growth factor-mediated inhibition of cell signalling and proliferation |
Route of administration | Oral |
Chemical structure | N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl) acetamide |
Pivotal trial(s) | Phase I [15, 26, 32], Phase II [15, 47], Phase III [14, 18, 19] |