Table 5.
Baseline characteristics of the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) cohort (n=7083)
| Characteristic | Result |
|---|---|
| Age at diagnosis years | 56±12 |
| Male sex | 4371 (62) |
| Ethnicity | |
| Caucasian | 6763 (96) |
| African-american | 106 (1) |
| Other | 214 (3) |
| BMI class kg-m−2 | |
| <18.5 | 464 (7) |
| 18.5−24.9 | 3060 (43) |
| 25−29.9 | 2376 (33) |
| ≥30 | 1183 (17) |
| Diagnosis delay years | 0.8 (0.4−1.3) |
| Symptom onset site | |
| Limb | 5517 (78) |
| Bulbar | 1566 (22) |
| FVC % predicted | 88±20 |
| ALSFRS-R total score | 37±6 |
| ALSFRS-R dyspnoea score | |
| 4 | 4887 (69) |
| 3 | 1133 (16) |
| 2 | 779 (1 1) |
| 1 | 213 (3) |
| 0 | 71 (1) |
| ALSFRS-R orthopnoea score | |
| 4 | 5902 (84) |
| 3 | 708 (10) |
| 2 | 334 (5) |
| 1 | 71 (1) |
| 0 | 48 (<1) |
Data are presented as n (%), mean±SD or median (interquartile range). BMI: body mass index; FVC: forced vital capacity; ALSFRS-R: amyotrophic lateral sclerosis functional rating scale-revised.