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. 2019 Aug 2;7(4):10.1128/microbiolspec.gpp3-0045-2018. doi: 10.1128/microbiolspec.gpp3-0045-2018

FIGURE 11.

FIGURE 11

(A) Induction of valvulitis and cellular infiltration in hematoxylin- and eosin-stained heart valves from Lewis rats immunized with group A streptococcal M5 peptides NT1 to NT4/5 (AVTRGTINDPQRAKEALD amino acid [aa] residues 1 to 18; NT-2 KEALDKYELENHDLKTKN aa residues 14 to 31; NT-3 LKTKNEGLKTENEGLKTE aa residues 27 to 44; NT-4 GLKTENEGLKTENEGLKTE aa residues 40 to 58; NT-4/5 GLKTEKKEHEAENDKLK aa residues 54 to 70). (Taken from Kirvan et al. [8] with permission from the Journal of Translational Cardiology.) (B) Induction of valvulitis, edema, and cellular infiltration in hematoxylin- and eosin-stained heart valves from Lewis rats immunized with group A streptococcal M5 peptides NT1 to NT4/5 (AVTRGTINDPQRAKEALD aa residues 1 to 18; NT-2 KEALDKYELENHDLKTKN aa residues 14 to 31; NT-3 LKTKNEGLKTENEGLKTE aa residues 27 to 44; NT-4 GLKTENEGLKTENEGLKTE aa residues 40 to 58; NT-4/5 GLKTEKKEHEAENDKLK aa residues 54 to 70). (Taken from Kirvan et al. [8] with permission from the Journal of Translational Cardiology.) (C) Verrucous nodule observed on Lewis rat valve after immunization with group A streptococcal rM6 protein. (Taken from Quinn et al. [23] with permission from Infection and Immunity.) (D) VCAM-1 expressed on rheumatic valve. (Taken from Roberts et al. [48] with permission from the Journal of Infectious Diseases.)