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. Author manuscript; available in PMC: 2020 May 28.
Published in final edited form as: J Control Release. 2019 Apr 8;302:181–189. doi: 10.1016/j.jconrel.2019.04.009

Fig. 3. Log inhibition curves (IC50) of C3 opsonization and C5a release in sera and plasma by SPIO NWs.

Fig. 3

SPIO NWs were incubated in sera and plasma in the presence or absence of increasing concentration of inhibitors as described in Methods. A) C3 deposition, SCR-2-3-4 in serum; B) C5a levels, SCR-2-3-4 in serum; C) C3 deposition, SCR-2-3-4 in plasma; D) C5a levels, SCR-2-3-4 in plasma; E) C3 deposition, soluble CD55 in serum; F) C3 deposition, SCR-2-3-4 and cP40 (compstatin) in plasma. Each graph shows a corresponding IC50 value above. Typical inhibition curve is shown; multiple donors are compiled in Table 1. All graphs show raw values on Y-axis. Each point is the average of 3 technical replicates.