Table 2:
| Adverse event (non-hematologic) | Advanced Phase* CML N (%) |
|---|---|
| Diarrhea | |
| All grade | 122 (74) |
| Grade 3/4 | 8 (5) |
| Nausea | |
| All grade | 80 (48) |
| Grade 3/4 | 3 (2) |
| Vomiting | |
| All grade | 72 (43) |
| Grade 3/4 | 6 (4) |
| Rash | |
| All grade | 51 (31) |
| Grade 3/4 | 6 (4) |
| Pyrexia | |
| All grade | 64 (39) |
| Grade ¾ | 5 (3) |
| Fatigue | |
| All grade | 35 (21) |
| Grade | 7 (4) |
| Abdominalpain | |
| All grade | 35 (21) |
| Grade ¾ | 4 (2) |
| Headache | |
| All grade | 31 (19) |
| Grade 3/4 | 7 (4) |
| Cough | |
| All grade | 34 (21) |
| Grade 3/4 | 0 |
| Elevated ALT | |
| All grade | 17 (10) |
| Grade 3/4 | 7 (4) |
| Upper abdominal pain | 17 (10 |
| All grade | 3 (2) |
| Grade 3/4 | |
| Elevated AST | |
| All grade | 17 (10) |
| Grade 3/4 | 5 (3) |
| Arthralgia | |
| All grade | 22 (13) |
| Grade 3/4 | 1 (1) |
| Decreased appetite | |
| All grade | 21 (13) |
| Grade 3/4 | 0 |
| Constipation | |
| All grade | 27 (16) |
| Grade 3/4 | 1 (1) |
| Dyspnea | |
| All grade | 32 (19) |
| Grade 3/4 | 9 (5) |
| Asthenia | 20 (12) |
| All grade | 1(1) |
| Grade 3/4 | |
| Dizziness | |
| All grade | 21 (13) |
| Grade 3/4 | 1 (1) |
| Peripheral edema | |
| All grade | 17 (10) |
| Grade 3/4 | 1 (1) |
| Extremity pain | |
| All grade | 18(11) |
| Grade 3/4 | 1 (1) |
| Pleural effusion | |
| All grade | 16 (10) |
| Grade 3/4 | 7 (4) |
| Adverse event (hematologic) | |
| Thrombocytopenia | |
| All grade | 74 (45) |
| Grade 3/4 | 65 (39) |
| Anemia | |
| All grade | 64 (39) |
| Grade 3/4 | 42 (25) |
| Neutropenia | |
| All grade | 36 (22) |
| Grade 3/4 | 33 (20) |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CML, chronic myeloid leukemia
*
Advanced phase CML included patients in accelerated phase, blast phase and patients with acute lymphoblastic leukemia