Table 3:
Adverse events (≥10%) following bosutinib in CML patients previously treated with imatinib and dasatinib32 (Reproduced with permission)
| Adverse event (non-hematologic) | Dasatinib-resistant (Total 38 patients) N (%) | Dasatinib-intolerant (Total 50 patients) N (%) |
|---|---|---|
| Diarrhea | ||
| All grade | 30 (79) | 42 (84) |
| Grade 3/4 | 3 (8) | 5 (10) |
| Nausea | ||
| All grade | 20 (53) | 23 (46) |
| Grade 3/4 | 1 (3) | 0 |
| Vomiting | ||
| All grade | 14 (37) | 24 (48) |
| Grade 3/4 | 1 (3) | 0 |
| Rash | ||
| All grade | 10 (26) | 18 (36) |
| Grade 3/4 | 0 | 3 (6) |
| Pyrexia | ||
| All grade | 6 (16) | 8 (16) |
| Grade 3/4 | 0 | 0 |
| Fatigue | ||
| All grade | 8 (21) | 14 (28) |
| Grade 3/4 | 0 | 1 (2) |
| Abdominal pain | ||
| All grade | 9 (24) | 12 (24) |
| Grade 3/4 | 0 | 1 (2) |
| Headache | ||
| All grade | 8 (21) | 14 (28) |
| Grade 3/4 | 1 (3) | 3 (6) |
| Cough | ||
| All grade | 7 (18) | 11 (22) |
| Grade 3/4 | 0 | 0 |
| Elevated ALT | ||
| All grade | 6 (16) | 6 (12) |
| Grade 3/4 | 0 | 4 (8) |
| Upper abdominal pain | ||
| All grade | 8 (21) | 9 (18) |
| Grade 3/4 | 0 | 0 |
| Arthralgia | ||
| All grade | 5 (13) | 10 (20) |
| Grade 3/4 | 0 | 1 (2) |
| Decreased appetite | ||
| All grade | 3 (8) | 7 (14) |
| Grade 3/4 | 0 | 1 (2) |
| Constipation | ||
| All grade | 2 (5) | 8 (16) |
| Grade 3/4 | 0 | 0 |
| Dyspnea | ||
| All grade | 2 (5) | 10 (20 |
| Grade 3/4 | 0 | 1 (2) |
| Back pain | ||
| All grade | 5 (13) | 5 (10) |
| Grade 3/4 | 0 | 2 (4) |
| Dizziness | ||
| All grade | 5 (13) | 8 (16) |
| Grade 3/4 | 0 | 0 |
| Peripheral edema | ||
| All grade | 1 (3) | 5 (10) |
| Grade 3/4 | 0 | 0 |
| Nasopharyngitis | ||
| All grade | 4 (11) | 5 (10 |
| Grade 3/4 | 0 | 0 |
| Extremity pain | ||
| All grade | 1 (3) | 5 (10 |
| Grade 3/4 | 0 | 0 |
| Pleural effusion | ||
| All grade | 5 (13) | 12 (24) |
| Grade 3/4 | 2 (5) | 2 (4) |
| Adverse event (hematologic) | ||
| Thrombocytopenia | ||
| All grade | 11 (29) | 19 (38) |
| Grade 3/4 | 7 (18) | 16 (32) |
| Anemia | ||
| All grade | 8 (21) | 7 (14) |
| Grade 3/4 | 3 (8) | 4 (8) |
| Neutropenia | ||
| All grade | 9 (24) | 7 (14) |
| Grade 3/4 | 6 (16) | 7 (14) |
Abbreviations: ALT, alanine aminotransferase; CML, chronic myeloid leukemia