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. Author manuscript; available in PMC: 2020 Aug 20.
Published in final edited form as: Gene. 2019 Jun 6;710:246–257. doi: 10.1016/j.gene.2019.06.005

Fig. 4.

Fig. 4.

Gene ontology analysis of predicted target genes of EV miRNAs revealed biological categories related to tumor progression and metastasis. Unsupervised hierarchical clustering analysis (Pearson correlation method) of robustly expressed EVs miRNAs in osteosarcoma or osteoblastic cell lines show miRNA clusters according to their high relative expression on each cell line (A). Gene ontology analysis of predicted target genes, revealed by TargetScan (http://www.targetscan.org/), associated to miRNA clusters showed in A was assessed using DAVID 6.8 (http://david.ncifcrf.gov/) to identify pathways and biological processes functionally linked to tumor progression and metastasis (B).