Table 3.
Large Kindreds With Initial Diagnosis of FIHP and a Later Clinical Diagnosis of a More Complex FH Syndrome
| Initial Report as FIHPa | Follow-Up Report as More Complex FH Syndrome | |||||
|---|---|---|---|---|---|---|
| First Author | Year | No. of Hyperparathyroid Cases | First Author | Year | Complex Diagnosis | Syndromal Trait |
| No author (24) | 1962 | 7 | No author (24) | 1969 | MEN1 | Islet, pituitary, and adrenocortical microadenomas |
| Goldsmith (25) | 1976 | 16 | Marx (26) | 1982 | MEN1 | Prolactinoma, insulinoma |
| Jackson (27) (abstract) | 1966 | 19 | Jackson (28) (abstract) | 1981 | FHH | Relative hypercalciuria failed parathyroidectomies |
| Spiegel (29) | 1977 | 12 | Marx (30) | 1982 | FHH | Relative hypocalciuria, failed parathyroidectomies |
| Marsden (31) | 1971 | 6 | Wassif (32) | 1999 | HPT-JT | Parathyroid cancer, jaw tumors |
a
The few kindreds with initial report of two cases of neonatal severe primary hyperparathyroidism (and follow-up report of FHH in relatives) are excluded from this table because this is not FIHP and does not constitute a large kindred in its initial report.