Table 5.
Testing polygenic moderation of intervention effects on symptom scales
| Polygenic Score (p = .05) | |||||||
|---|---|---|---|---|---|---|---|
| Est. | SE | P | Lower CI | Upper CI | R2 | ||
| General Anxiety | Intervention | −.192 | .221 | .385 | −.626 | .242 | .040 |
| Polygenic Score | .403* | .159 | .011 | .091 | .714 | ||
| Polygenic X Intervention | −.589** | .221 | .008 | −1.022 | −.157 | ||
| Separation Anxiety | Intervention | −.143 | 234 | 543 | −.601 | .316 | .031 |
| Polygenic Score | .273 | .169 | .106 | −.058 | .603 | ||
| Polygenic X Intervention | −.301 | .234 | .199 | −.760 | .158 | ||
| Social Anxiety | Intervention | −.035 | .301 | .908 | −.625 | .555 | .038 |
| Polygenic Score | .059 | .217 | .786 | −.366 | .484 | ||
| Polygenic X Intervention | −.463 | .301 | .125 | −1.053 | .128 | ||
| Specific Phobia | Intervention | −.030 | .171 | .859 | −.365 | .304 | .085 |
| Polygenic Score | .258* | .123 | .036 | .017 | .499 | ||
| Polygenic X Intervention | −.313 | .171 | .066 | −.648 | .021 | ||
| Obsessive Compulsive Symptoms | Intervention | .044 | .125 | .727 | −.201 | .288 | .059 |
| Polygenic Score | .248** | .090 | .006 | .073 | .424 | ||
| Polygenic X Intervention | −.300* | .124 | .015 | −.543 | −.058 | ||
| Major Depressive Symptoms | Intervention | −.468 | .431 | .278 | −1.313 | .377 | .018 |
| Polygenic Score | .450 | .309 | .145 | −.156 | 1.056 | ||
| Polygenic X Intervention | −.748 | .430 | .082 | −1.590 | .094 | ||
| Manic Symptoms | Intervention | −.013 | .237 | .957 | −.476 | .451 | .027 |
| Polygenic Score | .390* | .170 | .021 | .058 | .723 | ||
| Polygenic X Intervention | −.662** | .236 | .005 | −1.123 | −.200 | ||
| Polygenic Score (p = .10) | |||||||
| Est. | SE | p | Lower CI | Upper CI | R2 | ||
| General Anxiety | Intervention | −.201 | .222 | .364 | −.635 | .233 | .038 |
| Polygenic Score | .371* | .160 | .021 | .057 | .685 | ||
| Polygenic X Intervention | −.568** | .219 | .009 | −.997 | −.139 | ||
| Separation Anxiety | Intervention | −.144 | .234 | .537 | −.602 | .314 | .034 |
| Polygenic Score | .342* | .170 | .044 | .009 | .675 | ||
| Polygenic X Intervention | −.369 | .232 | .111 | −.823 | .085 | ||
| Social Anxiety | Intervention Polygenic Score | −.035 | .302 | .909 | −.626 | .557 | .032 |
| Polygenic Score | −.055 | .219 | .802 | −.485 | .375 | ||
| Polygenic X Intervention | −.182 | .299 | .543 | −.769 | .404 | ||
| Specific Phobia | Intervention | −.035 | .171 | .839 | −.369 | .300 | .083 |
| Polygenic Score | .238 | .124 | .055 | −.005 | .481 | ||
| Polygenic X Intervention | −.272 | .169 | .108 | −.603 | .059 | ||
| Obsessive Compulsive Symptoms | Intervention | .040 | .125 | .751 | −.205 | .284 | .059 |
| Polygenic Score | .240** | .090 | .008 | .063 | .416 | ||
| Polygenic X Intervention | −.307* | .123 | .012 | −.548 | −.066 | ||
| Major Depressive Symptoms | Intervention | −.488 | .432 | .258 | −1.334 | .358 | .016 |
| Polygenic Score | .232 | .312 | .457 | −.380 | .844 | ||
| Polygenic X Intervention | −.600 | .426 | .160 | −1.436 | .236 | ||
| Manic Symptoms | Intervention | −.035 | .237 | .882 | −.500 | .430 | .021 |
| Polygenic Score | .112 | .172 | .515 | −.225 | .448 | ||
| Polygenic X Intervention | −.483* | .234 | .040 | −.942 | −.023 | ||
Note. Child gender, age, monthly family income, and site were included as covariates in all models, but results are omitted to save space. No covariate significantly predicted symptom outcomes in any model.