TABLE 1-.
OTHER TRISOMIC CHROMOSOME CONDITIONS ASSOCIATED WITH RENAL AND URINARY TRACT ABNORMALITIES
| Chromosome aberrations | Renal abnormality | Reference |
|---|---|---|
| 1q23 or 5→qter trisomy | Renal cysts and calcification, hydronephrosis | 21, 22, 23 |
| 2q21→qter trisomy | Ectopic, dysplastic, and horseshoe kidneys; ureteral atresia | 24 |
| 2q3 trisomy | Vesicoureteral reflux | 25 |
| 3q2 trisomy | Cystic dysplasia, calcification, and duplication of kidney; accessory kidney | 26, 27 |
| 4p14→pter trisomy | Renal agenesis, rotated kidneys, intrarenal pelvis | 28, 29. |
| 4q2 or 3 trisomy | Cystic, hypoplastic, aplastic, and horseshoe kidney; vesicoureteral reflux; hydronephrosis; hydro ureter |
1, 30, 31 32 |
| 6p21→pter trisomy | Horseshoe and small kidney, triple renal artery, double renal vein | 33 |
| 6p2 trisomy | Proteinuria, small kidneys | 1, 34 |
| 6q21→qter trisomy | Renal dysplasia | 35 |
| 7q3 trisomy | Hydronephrosis, hydroureter | 36 |
| 8p trisomy | Ureteral stenosis, absent bladder | 1 |
| 8q2 trisomy | Hydronephrosis, hydroureter | 1 |
| 9 trisomy | Cystic kidneys | 37 |
| 9 trisomy mosaicism | Renal cysts | 38 |
| 9p trisomy | Hydronephrosis, horseshoe kidney | 39 |
| 9q3 trisomy | Hydroureter | 1 |
| 10 trisomy mosaicism | Immature glomeruli | 40 |
| 10p11→pter trisomy | Rotated, aplastic, cystic, dysplastic, and double kidneys; megaureter; aplastic ureter |
41,42,43 44, 45 |
| 10q2 trisomy | Renal failure; hypoplastic, dysplastic, cystic, hydronephrotic and double kidneys; double collection system |
46, 47 48, 49 |
| 11 p15 trisomy | Large kidneys, Wilms’tumor | 50 |
| 11q2 trisomy | Renal agenesis, vesicoureteral reflux | 51, 52 |
| 12q2 trisomy | Hydronephrosis, ureterocele, pelvic kidney | 53, 54 |
| 12q24.1→qter trisomy | Ureterocele, hydronephrosis, ectopic and aplastic kidney |
53,54 55 |
| 13q2 or 3 trisomy | Double renal artery, unspecified renal abnormalities | 56, 57 |
| 14 trisomy mosaicism | Renal failure | 1 |
| 17q21→qter trisomy | Hypoplastic and cystic kidneys, hyperplastic urinary bladder | 58 |
| 17q23→qter trisomy | Unspecified urinary tract malformations | 1 |
| 18pter→18q21.2 trisomy | Multicystic kidneys, ureteral agenesis | 59 |
| 18q2 trisomy | Polycystic and ectopic kidneys, vesicoureteral reflux, hydroureter, unspecified renal malformations | 1, 59, 60 |
| 19q13→pter trisomy | Hydronephrosis; hydroureter; ectopic, malrotated or cystic kidneys | 61, 62 |
| 20p trisomy | Hydronephrosis, polycystic kidneys, double collecting system | 63 |