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. Author manuscript; available in PMC: 2020 Sep 10.
Published in final edited form as: Stat Med. 2019 Jun 19;38(20):3936–3946. doi: 10.1002/sim.8212

Figure 1.

Figure 1.

Conceptual similarity between weighting protein sequences and weighting continuous biomarkers for maximum diversity. (a) A group of 3 amino acid sequences arranged vertically. Each sequence (seq.) is assigned a weight. The numbers 1, 2 and 3 index the positions (pos.) within a sequence. (b) A panel of 3 immune response biomarkers measured from three subjects. The biomarker values are represented by color-coded tickmarks. Each color (biomarker) is assigned a weight. The numbers 1, 2, and 3 index the subjects (subj.). The arrows represent the real lines, and the bell curves over the tickmarks illustrate kernel density estimation.