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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Jul 2;1866(10):1584–1594. doi: 10.1016/j.bbamcr.2019.06.019

Figure 6.

Figure 6.

The chromatin and methylome states of key genes required for retinal development in the Müller glia epigenome. A) Promoters of the optic vesicle and RPC phenotypes, and cell cycle-related genes are in a permissive (active/open) chromatin state and unmethylated or low-methylated (% - percent of genes in the respective states). B) Many promoters of genes required for the development and function of early-born retinal neurons are in a repressive (inactive) chromatin state, but they are mostly unmethylated or low-methylated. Promoters of late-born neurons are mostly in a permissive (active/open) chromatin state and unmethylated or low-methylated. However, promoters of some genes required for cone and rod phototransduction are highly methylated, which may affect the function of photoreceptors dedifferentiated from Müller glia. (hypoM – hypomethylated genes; hyperM – hypermethylated genes)