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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Nat Struct Mol Biol. 2019 Jul 15;26(8):712–719. doi: 10.1038/s41594-019-0268-0

Figure 1.

Figure 1

Overall structure of the full length TcdB holotoxin. (a) A schematic diagram showing the domain organization of TcdB and the approximate VHH-binding regions. GTD, glucosyltransferase domain (red); CPD, cysteine protease domain (light blue); DRBD, delivery and receptor-binding domain (yellow); CROPs, combined repetitive oligopeptides domain (blue). (b) Cartoon representations of TcdB holotoxin. The 3 VHHs that were used to facilitate crystallization were omitted for clarity. TcdB domains are colored as in panel (a).