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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Ann Surg Oncol. 2019 Jun 27;26(9):2821–2830. doi: 10.1245/s10434-019-07508-3

Figure 2: High CTL-TC mixing is associated with both a pro-inflammatory and immunosuppressive microenvironment.

Figure 2:

Patients were separated into cohorts by G-function with high value patients representing tumors with elevated CTL-TC mixing and a low value, the converse. Relative to patients with low CTL-TC mixing, those with a high degree of cellular mixing tended to have a greater infiltration of inflammatory cells defined as lymphocytes, dendritic cells and APCs (2a) and a higher infiltration of T cells (2b) with a greater relative ratio of cytotoxic lymphocytes (2c). Other differences included a higher proportion of Th cells of total cells (2d) while the relative amount of Tregs was similar (2e). Analysis of checkpoint expression revealed a greater proportion of PD-L1+ TCs (2f) APCs (2g,h).