Table 1.

Antibacterial activity of amSPC compounds

		MIC (µg ml-1)
Pathogen		1950	1951	2241	2324	SPTa
B. mallei	MIC Rangeb	3.13–50	3.13–50	3.13–50	1.56–50	8–16
	MIC50	6.3	6.3	6.3	6.3	8
	MIC90	12.5	12.5	12.5	12.5	16
Brucella spp.c	MIC Rangeb	0.4–12.5	0.4–12.5	0.4–12.5	≤0.2–6.3	1–32
	MIC50	1.56	3.13	1.56	1.56	4
	MIC90	3.13	6.25	3.13	6.25	8
F. tularensis	MIC Rangeb	1.56–200	3.13–200	3.13–200	1.56–200	1->64
	MIC50	12.5	6.25	12.5	6.25	64
	MIC90	100	50	50	50	>64
B. anthracis	MIC Rangeb	12.5–100	6.25–50	3.13–25	12.5–50	16->64
	MIC50	25	25	12.5	25	64
	MIC90	50	50	12.5	25	64
Y. pestis CO92	MIC	50	50	25	50	32
B. pseudomallei d	MIC	>200	>200	>200	>200	>64

^aSPT: spectinomycin

^bThe range of MIC values for 29 strains of B. mallei, 29 strains of Brucella spp., 26 strains of F. tularensis, and 30 strains of B. anthracis

^cBrucella species tested: B. abortus, B. suis, and B. melitensis

^dMIC was the same for all 10 B. pseudomallei strains tested