Table 2.
FIC indices for spectinomycin and compound 1950 in combination with other antibiotics
| Bacterial strain | B. pseudomallei K96243 | B. mallei FMH | B. anthracis Ames | B. suis | F. tularensis SchuS4 | Y. pestis CO92 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC used for FIC calculationa | 0.5 X MIC | 0.25 X MIC | 0.5 X MIC | 0.25 X MIC | 0.5 X MIC | 0.25 X MIC | 0.5 X MIC | 0.25 X MIC | 0.5 X MIC | 0.25 X MIC | 0.5 X MIC | 0.25 X MIC |
| Spectinomycin FIC | ||||||||||||
| Doxycycline | 1.5 | 1.25 | 0.62 | 0.5 | 0.75 | 0.75 | 0.74 | 1.25 | 0.625 | 0.75 | 0.75 | 0.75 |
| Ciprofloxacin | – | – | – | – | 1.5 | 1.25 | – | – | 1.5 | 2.25 | 0.74 | 0.49 |
| Streptomycin | – | – | – | – | 2.5 | 2.25 | 1.5 | 1.25 | 2.5 | 2.25 | 1 | 1.25 |
| Chloramphenicol | – | – | – | – | – | – | – | – | 0.75 | 0.75 | 1 | 1.25 |
| Clarithromycin | – | – | – | – | 1 | 0.75 | – | – | – | – | – | – |
| Trimethoprim | 1.5 | 1.25 | 0.50 | 0.375 | – | – | 1.5 | 1.25 | – | – | n.d.b | n.d.b |
| Ceftazidime | 1.5 | 0.75 | 1 | 0.75 | – | – | – | – | – | – | – | – |
| 1950 FIC | ||||||||||||
| Doxycycline | 2.5 | 1.25 | 0.62 | 0.75 | 0.75 | 0.75 | 0.74 | 1.25 | 0.75 | 0.75 | 0.625 | 0.75 |
| Ciprofloxacin | – | – | – | – | 2.58 | 2.33 | – | – | 1.5 | 1.25 | 1 | 1.25 |
| Streptomycin | – | – | – | – | 4.5 | 4.25 | 2.5 | 1.25 | 2.5 | 2.25 | 1.5 | 1.25 |
| Chloramphenicol | – | – | – | – | – | – | – | – | 1.0 | 0.75 | 0.75 | 0.75 |
| Clarithromycin | – | – | – | – | 1 | 0.75 | – | – | – | – | – | – |
| Trimethoprim | 1.5 | 1.25 | 0.56 | 1.25 | – | – | 1.5 | 1.25 | – | – | 0.75 | 0.75 |
| Ceftazidime | 2.5 | 2.25 | 0.75 | 1.25 | – | – | – | – | – | – | – | – |
aMIC of Spectinomycin or compound 1950 used for FIC calculation
bCould not be calculated