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. 2019 Aug 6;8(8):40. doi: 10.1038/s41389-019-0149-8

Fig. 7. Scheme for Hic-5 mediated positive feedback NADPH oxidase-ROS-JNK-c-jun cascade, regulating EMT markers.

Fig. 7

According to the data shown in this report, Hic-5 can be induced by ROS-JNK pathway and transactivated by c-jun and AP4 which may in turn interact with Rac1 and Traf4, and Pyk2 triggering activation of NADPH oxidase, ROS generation and JNK phosphorylation thus sustaining the signal transduction. In this way, Hic-5 may play a central role in mediating the positive feedback ROS-JNK signaling circuit which upregulates Snail, Zeb-1, and MMP-9 and downregulate E-cadherin for triggering HCC migration and progression of HCC