Fig. 5.

Meta-MARC recovers > 90% of simulated reads despite many random point mutations and moderate (25%) contiguous randomization. Percent of genes classified correctly (recovered) is negatively associated with the proportion of the reference sequence randomized before simulation for all methods. Contiguous randomizations (insertion/deletions) demonstrate a consistent negative trend for all methods. Noncontiguous, random point mutations are tolerated well by Meta-MARC Assembly, moderately well for Meta-MARC HTS, and poorly for Alignment and Resfams. Each data point represents a unique annotation Class. The lines were fit using LOESS regression in R, and the gray area is the standard error of the LOESS fit