Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 6;10:3435. doi: 10.1038/s41467-019-11410-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — Fuzzy electrostatic interactions promote acetylation of lysine residues in the H3 tail. Left, the mechanism of chaperoning H3-K56 to the Rtt109 catalytic pocket is based on well-known enzyme-recruitment and substrate-presentation processes. Right, the mechanism by which Vps75 chaperones lysine residues in the H3 tail to the Rtt109 catalytic pocket differs from the canonical substrate-presentation process and includes confinement of the H3 tail in the proximity of the Rtt109 catalytic pocket via fuzzy electrostatic interactions occurring between two disordered protein domains, the Vps75 CTAD and the H3 tail.