Fig. 2.

Angptl8 resets liver clock in vivo. a Representative actograms of the wheel-running activities of mice i.p. injected recombinant Angptl8 or vehicle (PBS) for 24 consecutive days at ZT2 (or CT2 when mice switched to DD). n = 5. b Calculation of mouse circadian period in a. c Calculation of mouse circadian phase shift in a. *P < 0.05 and **P < 0.01 Angptl8 vs. PBS, one-way ANOVA followed by Bonferroni’s post hoc test. d, e qPCR analyses of clock and metabolic genes expression in the liver of mice receiving 15-day injection with recombinant Angptl8 or vehicle (PBS) at ZT2. n = 5, *P < 0.05 and **P < 0.01 Angptl8 vs. PBS at the same time point, two-way ANOVA followed by Bonferroni’s post hoc test. f Serum levels of TG, TC and glucose in d. All data are presented as the means ± SD. Source data are provided as a Source Data file