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. 2019 Aug 6;9:11359. doi: 10.1038/s41598-019-47837-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative confocal images of tumorigenic proteins in PRP treated pancreatic CSCs versus non-treated CSCs. (A) Treatment with PRP maintain membrane-associated β-catenin without nuclear translocation in pancreatic CSCs. (B) PRP treatment increased membrane-associated E-cadherin. Cell surface β-catenin and E-cadherin expression was detected in red and nuclei were counterstained with DAPI (blue). Scale bar represents 20 μm. (C) PRP treatment decreased the protein expression of YAP in BxPC3 CSCs. YAP expression appears green and nuclei stained with DAPI (blue). Scale bar represents 10 μm. (D) Western blot analysis of YAP and p-YAP proteins in CSCs treated with PRP versus non-treated. A negative correlation between YAP and p-YAP expression was found.