Table 3.
Stability of 225Ac-labelled chelate complexes in human serum at ambient Temperatures (n = 3 unless otherwise noted)
| 225Ac-complex | Time Point | |||||||
|---|---|---|---|---|---|---|---|---|
| % Stable | 0.5 h | 1 h | 4 h | 1 d | 2 d | 3 d | 4 d | 7 d |
| [225Ac(octapa)]− | NDa | 97.9 ± 0.9 | 96.9 ± 1.5 | 94.9 ± 1.2 | 96.1 ± 1.0 | 94.9 ± 1.1 | 95.9 ± 1.9 | 92.9 ± 1.0 |
| [225Ac(CHXoctapa)]− b | NDa | 95.9 ± 1.0 | 96.8 ± 1.7 | 97.0 ± 0.9 | 96.7 ± 1.6 | 96.1 ± 1.5 | 96.7 ± 1.2 | 95.6 ± 1.6 |
| [225Ac(phospa)]3− | NDa | 81.6 ± 1.1 | NDa | 81.5 ± 0.2 | NDa | 80.2 ± 1.1 | 76.2 ± 0.1 | 77.1 ± 6.4 |
| [225Ac(DOTA)]− | 92.4 ± 4.0 | 93.9 ± 4.5 | 94.4 ± 3.7 | 90.9 ± 5.6 | 91.8 ± 5.6 | NDa | 91.1 ± 6.1 | 84.7 ± 8.1 |
| [225Ac(macropa)]+ (Thiele et al. 2017) c | 96 | 95 | 93 | 90 | 93 | 90 | NDa | 90 |
| [225Ac(bispa2)]+ (Comba et al. 2017) | NDa | 97.4 ± 0.5 | NDa | 92.3 ± 0.7 | NDa | 90.7 ± 0.5 | NDa | 88.9 ± 2.8 |
| Control | 1.45 ± 3.8 | 1.29 ± 4.0 | 1.6 ± 3.5 | 2.6 ± 5.0 | 3.9 ± 3.0 | NDa | 0.96 ± 3.3 | 1.5 ± 4.1 |
aND not determined; bn = 4; cn = 1