Table 4.
Stability of 225Ac-Labelled Chelate Complexes in 50-fold excess LaIII at ambient temperature
| Ligand | % stable | ||||||
|---|---|---|---|---|---|---|---|
| Time point: | 1 h | 5 h | 1 d | 2 d | 3 d | 6 d | 7 d |
| [225Ac(octapa)]− (n = 2) | 78.9 ± 2.9 | 42.7 ± 0.3 | 4.7 ± 1.5 | 6.1 ± 2.6 | NDa | NDa | NDa |
| [225Ac(CHXoctapa)]− (n = 2) | NDa | 81.8 ± 4.3 | 45.7 ± 3.1 | 26.5 ± 8.9 | 18.1 ± 0.4 | 5.0 ± 0.4 | 3.9 ± 0.6 |
| [225Ac(phospa)]3− (n = 3) | 0 | 0 | NDa | NDa | NDa | NDa | NDa |
| [225Ac(DOTA)]− (n = 2) | 95.2 ± 3.3 | 94.5 ± 3.5 | 94.9 ± 2.9 | 86.2 ± 3.1 | NDa | NDa | 77.1 ± 3.6 |
| [225Ac(macropa)]+ (Thiele et al. 2017) | 95 | NDa | 93 | 92 | 91 | 93 | 91b |
| [225Ac(bispa2)]+ (Comba et al. 2017) | NDa | 95.5 ± 0.2 | 91.5 ± 0.7 | 88.8 ± 2.5 | 85.2 ± 1.7 | 74.4 ± 1.4 | 71.1 ± 2.7 |
aND not determined. b8 d time point