Table 5.

Summary of in vivo biodistribution studies of [²²⁵Ac]Ac-CCZ01048 at 2 h post-injection. Statistical analysis between non-blocked and blocked experiments was performed using the Student’s t-test (* p < 0.05; ** p < 0.005; n = 4 for each animal experiment)

Study	Molar activity (kBq/nmol)	Tumour (%ID/g)	Kidney (%ID/g)	Blood (%ID/g)	Tumour: blood	Tumour: bone	Tumour: kidney
Non-blocked	>  200	5.23 ± 1.78	4.83 ± 1.58	0.25 ± 0.07	20.42 ± 3.38	23.16 ± 10.32	1.09 ± 0.11
Blocked	1.6	1.15 ± 0.21**	8.85 ± 1.19*	0.34 ± 0.09	3.50 ± 0.72**	1.22 ± 0.27**	0.13 ± 0.04**