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. 2019 Jul 31;13:799. doi: 10.3389/fnins.2019.00799

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Copyright © 2019 Crabbé, Van der Perren, Bollaerts, Kounelis, Baekelandt, Bormans, Casteels, Moons and Van Laere.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal follow-up of motor impairment in viral vector and toxin-based models. (A) Striatal 6-OHDA injection is associated with partial lesioning of the motor pathway. Both groups exhibit recovery of motor impairment over time. (B) Nigrostriatal α-synucleinopathy leads to significant limb-use asymmetry progressively deteriorating from 2 weeks post-injection. Data are represented as mean ± SEM. ^∗p < 0.05, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001, 2-way repeated measures ANOVA with Sidak post hoc tests.