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. 2019 Jul 31;13:168. doi: 10.3389/fnbeh.2019.00168

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Copyright © 2019 Yousuf, Smies, Hafenbreidel, Tuscher, Fortress, Frick and Mueller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bath-application of E₂ potentiates IL-mPFC pyramidal neuron excitability. (A) Photomicrograph of a biocytin-filled IL-mPFC pyramidal neuron. Scale bar, 50 μm. (B) Individual traces of current-evoked action potentials (APs) from IL-mPFC pyramidal neurons before (top) and after (bottom) bath-application of E₂ in slices from ovariectomized (OVX) female rats that were systemically injected with 2-hydroxypropyl-β-cyclodextrin (HBC)-vehicle (left) or with E₂ (right). Scale bars, 10 mV (vertical) and 500 ms (horizontal). (C) Compared to artificial cerebral spinal fluid (aCSF) alone (n = 10), bath-application of E₂ (n = 10) enhances intrinsic excitability in IL-mPFC neurons from OVX female rats that were systemically injected with HBC-vehicle prior to recordings. (D) Compared to aCSF alone (n = 9), bath-application of E₂ (n = 9) does not enhance intrinsic excitability in IL-mPFC neurons from OVX female rats that were systemically injected with E₂ prior to recordings. *p < 0.05. Error bars indicate SEM.