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Injections of selective TrkB receptor antagonist disrupted E2-induced facilitation of extinction of a cocaine CPP. Systemic injections (arrows) of E2 + ANA-12 (n = 9) but not E2 + vehicle (n = 10) before the first four CPP trials impaired extinction. ***p < 0.001, **p < 0.01, and *p < 0.05. Error bars indicate SEM.
