Table 1.
Effects of E2 on intrinsic excitability of infralimbic-medial prefrontal cortex (IL-mPFC) pyramidal neurons.
| Group | Time | RN (MΩ) | VRest (MΩ) | Rheobase (pA) | Threshold (mV) | Amplitude (mV) | Half width (ms) | sAHP (ms) | mAHP (ms) | fAHP (ms) |
|---|---|---|---|---|---|---|---|---|---|---|
| Systemic HBC | Pre E2 | 272.3 ± 33.3 | −58.9 ± 0.5 | 29.0 ± 3.8 | −35.8 ± 0.6 | 73.5 ± 3.0 | 1.0 ± 0.1 | 0.0 ± 0.2 | 2.2 ± 0.5 | 19.0 ± 1.1 |
| Post E2 | 308.0 ± 39.5* | −58.5 ± 0.7 | 18.0 ± 3.2* | −38.3 ± 0.8** | 71.5 ± 3.5 | 1.0 ± 0.1 | 0.2 ± 0.2 | 2.3 ± 0.5 | 16.1 ± 1.1* | |
| Systemic HBC | Pre E2 + K-252a | 291.7 ± 42.2 | −59.7 ± 0.5 | 35.7 ± 4.8 | −34.0 ± 0.6 | 67.8 ± 3.3 | 1.4 ± 0.1 | 0.2 ± 0.2 | 3.9 ± 0.7 | 22.7 ± 1.1 |
| Post E2 + K-252a | 329.7 ± 41.5* | −60.7 ± 0.4 | 37.1 ± 5.7 | −35.4 ± 0.5 | 64.3 ± 3.5 | 1.5 ± 0.1 | 0.4 ± 0.2 | 4.1 ± 0.7 | 22.9 ± 0.8 | |
| Systemic E2 | Pre E2 | 282.3 ± 35.3 | −59.9 ± 0.6 | 33.3 ± 5.8 | −35.3 ± 1.0 | 72.5 ± 2.6 | 1.3 ± 0.1 | 0.1 ± 0.3 | 2.5 ± 0.8 | 19.6 ± 1.5 |
| Post E2 | 318.0 ± 45.1* | −58.5 ± 0.5 | 26.7 ± 6.0* | −37.2 ± 1.1** | 71.4 ± 2.7 | 1.3 ± 0.1 | 0.0 ± 0.2 | 2.3 ± 0.4 | 17.6 ± 1.4 |
E2, 17β-estradiol; RN, input resistance; Vrest, resting potential; sAHP, slow afterhyperpolarization; mAHP, medium afterhyperpolarization; fAHP, fast afterhyperpolarization. *p < 0.05, **p < 0.001.