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. 2019 Jul 31;13:168. doi: 10.3389/fnbeh.2019.00168

Table 1.

Effects of E2 on intrinsic excitability of infralimbic-medial prefrontal cortex (IL-mPFC) pyramidal neurons.

Group Time RN (MΩ) VRest (MΩ) Rheobase (pA) Threshold (mV) Amplitude (mV) Half width (ms) sAHP (ms) mAHP (ms) fAHP (ms)
Systemic HBC Pre E2 272.3 ± 33.3 −58.9 ± 0.5 29.0 ± 3.8 −35.8 ± 0.6 73.5 ± 3.0 1.0 ± 0.1 0.0 ± 0.2 2.2 ± 0.5 19.0 ± 1.1
Post E2 308.0 ± 39.5* −58.5 ± 0.7 18.0 ± 3.2* −38.3 ± 0.8** 71.5 ± 3.5 1.0 ± 0.1 0.2 ± 0.2 2.3 ± 0.5 16.1 ± 1.1*
Systemic HBC Pre E2 + K-252a 291.7 ± 42.2 −59.7 ± 0.5 35.7 ± 4.8 −34.0 ± 0.6 67.8 ± 3.3 1.4 ± 0.1 0.2 ± 0.2 3.9 ± 0.7 22.7 ± 1.1
Post E2 + K-252a 329.7 ± 41.5* −60.7 ± 0.4 37.1 ± 5.7 −35.4 ± 0.5 64.3 ± 3.5 1.5 ± 0.1 0.4 ± 0.2 4.1 ± 0.7 22.9 ± 0.8
Systemic E2 Pre E2 282.3 ± 35.3 −59.9 ± 0.6 33.3 ± 5.8 −35.3 ± 1.0 72.5 ± 2.6 1.3 ± 0.1 0.1 ± 0.3 2.5 ± 0.8 19.6 ± 1.5
Post E2 318.0 ± 45.1* −58.5 ± 0.5 26.7 ± 6.0* −37.2 ± 1.1** 71.4 ± 2.7 1.3 ± 0.1 0.0 ± 0.2 2.3 ± 0.4 17.6 ± 1.4

E2, 17β-estradiol; RN, input resistance; Vrest, resting potential; sAHP, slow afterhyperpolarization; mAHP, medium afterhyperpolarization; fAHP, fast afterhyperpolarization. *p < 0.05, **p < 0.001.