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. 2019 Jul 31;10:1778. doi: 10.3389/fimmu.2019.01778

Figure 1.

Figure 1

Cell-mediated reactivity against DENV-1,-2,-3, and-4 structural proteins following TAK-003 administration. (A) Schematic representation of the genetic structure of the tetravalent TAK-003 vaccine platform. Key attenuating mutations in the 5′ UTR, NS1, and NS3 are indicated by the yellow stars. (B) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-1 CprM/E peptide stimulation at the indicated time points following vaccination. (C) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-2 CprM/E peptide stimulation at the indicated time points following vaccination. (D) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-3 CprM/E peptide stimulation at the indicated time points following vaccination. (E) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-4 CprM/E peptide stimulation at the indicated time points following vaccination. (F) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-1,-2,-3, and-4 CprM/E peptide stimulation at day 120 post vaccination. n = 60 for days 0 and 28, n = 54 for day 120. *p < 0.05, **p < 0.01, ****p < 0.0001, ns, not significant Paired two-tailed t-test. Bars indicate group mean ± SEM. Zero values were superimposed on the logarithmic graph.