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. 2019 Jul 31;10:1778. doi: 10.3389/fimmu.2019.01778

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Copyright © 2019 Waickman, Friberg, Gargulak, Kong, Polhemus, Endy, Thomas, Jarman and Currier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell-mediated reactivity against DENV2 non-structural proteins following TAK-003 administration. (A) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-2 NS1 peptide stimulation at the indicated time points following vaccination. (B) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-2 NS2a/b peptide stimulation at the indicated time points following vaccination. (C) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-2 NS3 peptide stimulation at the indicated time points following vaccination. (D) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-2 NS4a/b peptide stimulation at the indicated time points following vaccination. (E) Frequency of IFN-γ producing cells as quantified by ELISPOT following DENV-2 NS5 peptide stimulation at the indicated time points following vaccination. (F) Relative distribution and magnitude of DENV2 reactivity at day 28 and 120 post vaccination. Numbers at the top of each bar indicate average number of Spot Forming Cells (SFCs) per million PBMCs observed in response to DENV-2 stimulation in all subjects at the relevant time points. n = 60 for days 0 and 28, n = 54 for day 120. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001 Paired two-tailed t-test. Bars indicate group mean ± SEM. Zero values were superimposed on the logarithmic graph.