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. 2019 Jul 31;11:198. doi: 10.3389/fnagi.2019.00198

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Copyright © 2019 Lubec, Smidak, Malikovic, Feyissa, Korz, Höger and Lubec.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Venn diagram showing the relationship between AI vs. young, AU vs. young, and AU vs. AI significant proteins. (B) Analysis of variance (ANOVA) of protein levels revealed a significant increase in SD with age and with cognitive impairment (one-way ANOVA, t-test post hoc test). (C–E) Functional enrichment analysis was performed on the list of significantly changed proteins between young and two aging groups using ClueGO-Cytoscape platform (Benjamini–Hochberg P-values < 0.05). Displayed gene ontology (GO) terms are the most significant cases from significantly enriched clusters. GO terms in the frames were significantly enriched only in one group AU vs. young or AI vs. young. (F) Significantly enriched GO terms in the set of 77 proteins with different protein levels between AU and AI.