Table 1.

Diagnostic classification of respiratory symptoms [5]

CTCAE gradea (dyspnea, cough, fever)	PFT declineb	Chest CT parenchymal abnormalities	Infectious analysis	Conclusionc
0	Non-significant	Absent	–	No ILD
		Present	–	Suspected ILD
	Significant	Absent	General	Inconclusive
		Present	General + consider BAL	ILD
1 or 2	Non-significant	Absent	General	Airway disease
		Present	General + consider BAL	Suspected ILD
	Significant	Absent	General + consider BAL	Suspected ILD
		Present	General + BAL	ILD
3 or 4	Non-significant	Absent	General + consider BAL	Inconclusive
		Present	General + BAL	ILD
	Significant	Absent	General + BAL	Inconclusive
		Present	General + BAL	ILD

CTCAE Common Terminology Criteria for Adverse Events, PFT pulmonary function test, ILD interstitial lung disease, BAL bronchoalveolar lavage, DLCOc diffusion capacity of the lungs for carbon monoxide corrected for hemoglobin

^aCTCAE pneumonitis NOT included

^bSignificant PFT decline defined as: DLCOc corrected for Hb decline ≥ 2 SD compared to baseline AND/OR FVC decline ≥ 2 SD compared to baseline

^cProvided that other possible diagnoses are considered or excluded, such as pulmonary infection, congestive heart failure, pulmonary embolism, carcinomatous lymphangitis or pleuritis, radiation recall pneumonitis, asthma bronchiale, or gastroesophageal reflux